"Wine" is "the razor's edge"
The acceptable apex on the quest for any pleasure, the final product of the vine.
Every man must know how much "wine" he can drink without crossing the "edge".
A buzz that is reached and even maintained is that edge. Once you cross over into actual drunkeness, you have crossed the line, and will receive a witness to that fact, in that you will either suffer from doing something stupid, have a hangover, get sick, etc.
I believe just the desire for wine also presents the same "line in the sand" effect, in that even if you don't get drunk, if you yearn for the daily drink to the point that you "can't do without it" and act crazy to get it, you have also seen the line.
Matthew 26:27 has been translated as "drink of it, all of you" when it should be "drink of it, all of it"
One wine that we are allowed (commissioned even) to cross the line and get drunk on, His cry for our salvation.
If you can police yourself on that "it's time to stop" line with alcohol, video games, body building, whatever... You're good to go.
Otherwise, all of those things are drunkenness, too much "wine"
Peace.