Communication will go a long way. Be careful to not throw the "I told you so", or "this is what you should do" cards. Noone will respond to those except in a negative way. Prayer is always the first line of defense, giving your marriage, family, and her business to God. Pray with her, over her, and be there to support her in every way. Businesses fail every day, but, God never does. If you as a couple will hit your knees before God, asking for His guidance, strength, and provision, for your family, marriage, and business, He will be faithful and guide you to what to do. He will also use you as an example for your wife if you will not only say you are the spiritual head of the home, but demonstrate it. Show her by example that you are going to follow God and give this all to Him. Your words will never change her, but, your actions will. Let her know that no matter what happens to the business, you are there for her, and that you do not appreciate your child being used as a bargaining tool and that your family deserves better than that. God bless you and I pray He will be at work in your lives.
Tithing is also key to making a business work. If she is not tithing her business, maybe starting would help. This is the only time in the Word that God tells us to try Him on something. He will honor the tithes given and use this business in a mighty way if she will be obedient.