I will be 62 soon. I used to be young. I (kind of) wish I could be young again. If I were to have a face lift and inject my muscles with silicone so it looked like I were strong, that would not make me any younger or stronger.
My chromosomes are male. If I went through the surgery to change how I look, I would still be male, I would just look different.
Looking different does not change the fact that you are who you are. Having surgery to look like your fantasy does not change the truth of who you are. (I have seen photos of people doing some pretty drastic things to their body, like implanting horns, or getting tattoos that make them look like a cat.) This only changes the way you look. It has nothing to do with who you really are.
Some people are old, some are young, some are tall, some are short, some are smart, some not so, some have one color of skin, others have another. God even designs people born blind to honor Him. (See John Ch 9.) God designed all of us to fit within His plan and we best honor Him when we accept the way He made us and live our lives to honor Him.
Nick Vujicic was born with no arms or legs. (lifewithoutlimbs.com) He has spoken to far more people about Christ that I ever expect to. He is honoring God as he was made. Everyone is responsible to honor God the way God made them.
Living in denial of who we are and in fantasy about how we wish were different does not draw us closer to God. It separates us further from Him
But again (as I posted previously), non-Christians, as a whole, have no interest in drawing closer to God through the death, burial, and resurrection of God's one and only Son, Messiah Jesus, or honoring Him with their lives.
So how can we expect them to be willing to conform to God's plan for their lives? (If they did, they would start by accepting Messiah Jesus as their Savior and Lord.)
It is regrettable that our world has fallen into such delusion and deception, but, it IMO is not likely to change anytime soon.
So, our response to "trans-gendered" people should be to show them how God loves them and to lead them to accept that God loves them so much that He sent His one and only human born Son to die in their place and that three days later, God raised Him from the dead.
Indeed, that should be our attitude toward everyone.