I couldn't say, since I am rather shy and would prefer NOT to talk with people of the opposite sex unless I'm rather well acquainted with them already by group activity and discussions.
But a real, sincere "How are you?" is lovely. If you really know someone, you'll know if they really mean that when they say it, or if it is just a throw off. I have a few friends who really care about the answer, and you surely can tell! Nothing makes you feel as good as someone who really cares how you are.