On the sardonic side:
Wow! I'm totally inspired. I'll just change my gender, and then I can come down heavy on all the women in the BDF because women can't be in ministry.
No more Greek, showing the real meanings of the word, no more praying for God's will. Just walk into my friendly neighbourhood church, show them my credentials and voilà, I am eligible for any pastorate in the world! Well, unless they don't favour transgendered people. I think I just have to channel my "inner tomboy" a bit.
On a more serious note, I think this is a serious issue, and not well understood. I met a man who was what seemed to be a normal male, fathered a daughter, but who was transgendered. He was a big guy, and I watched him and supported him as he transitioned. He was a strong Christian, took his Bible everywhere, witnessed to people and loved Jesus.
As I watched her become a different gender, which didn't seem possible in the beginning, she became happier, more vibrant and alive. She did not, to my knowledge, have any chromosome abnormalities. And she held onto Christ even more. She even tried a church where Jesus and Gaia were worshipped and decided to go back to a conservative church where the Bible was preached!
I don't claim to understand, and there probably are some spurious cases. I will leave their gender and salvation up to God!
Chromosome abnormalities are only part of it. What most people don't understand is just how many chemicals that we use now a days are ENDOCRINE INHIBITORS. Some are even used as SYNTHETIC hormones. Some of these chemicals they are just now finding out the long term affects such as PCB's,DES (a synthetic estrogen) ,BPA (Which can mimic estrogen),Etc,etc,etc this is JUST A PARTIAL list,notice how many of them act as estrogen blockers and how many are testoterone blockers? They don't even mention that.
Persistent organohalogens
[TABLE="width: 100%"]
[TR]
[TD="width: 36%"]
Compound(s)
[/TD][TD="width: 26%"]
Hormone system affected
[/TD][TD="width: 20%"]
Mechanism if known
[/TD][TD="width: 18%"]
References
[/TD][/TR]
[TR]
[TD="width: 36%"]Benzenehexachloride (BHC)[/TD]
[TD="width: 26%"]
Thyroid
[/TD][TD="width: 20%"][/TD]
[TD="width: 18%"] [/TD]
[/TR]
[TR]
[TD="width: 36%"]1,2-dibromoethane[/TD]
[TD="width: 26%"]
Reproductive
[/TD][TD="width: 20%"][/TD]
[TD="width: 18%"] [/TD]
[/TR]
[TR]
[TD="width: 36%"] Chloroform[/TD]
[TD="width: 26%"]
Reproductive
[/TD][TD="width: 20%"][/TD]
[TD="width: 18%"] [/TD]
[/TR]
[TR]
[TD="width: 36%"] Dioxins and furans
(in order of antiestrogenic potency : 2,3,7,8-tetrachlorodibenzo-p-dioxin > 2,3,7,8-tetrachlorodibenzofuran > 2,3,4,7,8-pentachlorodibenzo-furan > 1,2,3,7,9-pentachlorodibenzofuran > 1,3,6,8-tetrachlo-rodibenzofuran)[/TD]
[TD="width: 26%"]
Estrogen
[/TD][TD="width: 20%"]
work as anti-estrogen through binding with Ah receptor, which then inhibits estrogen receptor binding to estrogen response elements, thereby inhibiting estrogen action
[/TD][TD="width: 18%"] [/TD]
[/TR]
[TR]
[TD="width: 36%"]Octachlorostyrene[/TD]
[TD="width: 26%"]Thyroid[/TD]
[TD="width: 20%"][/TD]
[TD="width: 18%"]Sandan et al. 2000[/TD]
[/TR]
[TR]
[TD="width: 36%"] PBBs[/TD]
[TD="width: 26%"]
Estrogen/ Thyroid
[/TD][TD="width: 20%"][/TD]
[TD="width: 18%"] Bahn et al. 1980
Henderson et al. 1995[/TD]
[/TR]
[TR]
[TD="width: 36%"] PCBs
(in order of antiestrogenic potency: 3,3' -pentachlorobiphenyl > 3,3,4,4,5,5'-hexachlorobiphenyl 3,3',4,4-tetrachlorobiphenyl > 2,3,3',4,4',5'-hexa, 2,3,3',4,4'- and 2,3,4,4',5-pentachlorobiphenyl > Aroclors 1221, 1232. 1248, 1254, and 1260 were inactive as antiestrogens at the highest concentrations used in this study (10-6 Ni)
[/TD][TD="width: 26%"]
Estrogen/androgen/Thyroid
Adverse outcomes in reproductive systems.
[/TD][TD="width: 20%"]
Inhibits estrogen binding to the receptor; works as anti-estrogen.
anti-androgenic via Ah receptor interaction
[/TD][TD="width: 18%"] [/TD]
[/TR]
[TR]
[TD="width: 36%"]PCB, hydroxylated[/TD]
[TD="width: 26%"]
Thyroid
[/TD][TD="width: 20%"]
Binds to thyroid hormone binding protein, but not to the thyroid hormone receptor.
[/TD][TD="width: 18%"] [/TD]
[/TR]
[TR]
[TD="width: 36%"]PBDEs[/TD]
[TD="width: 26%"]
Thyroid
[/TD][TD="width: 20%"]
Interfere with thyroxine (T4) binding with transthryetin
[/TD][TD="width: 18%"] Ilonka et al. 2000[/TD]
[/TR]
[TR]
[TD="width: 36%"]Pentachlorophenol[/TD]
[TD="width: 26%"]
Thyroid
[/TD][TD="width: 20%"]
Reduces thyroid hormone possibly through a direct effect on the thyroid gland.
[/TD][TD="width: 18%"] [/TD]
[/TR]
[/TABLE]
Food Antioxidant
[TABLE="width: 100%"]
[TR]
[TD]
Compound
[/TD][TD]
Hormone system affected
[/TD][TD]
Mechanism
[/TD][TD]
References
[/TD][/TR]
[TR]
[TD] Butylated hydroxyanisole (BHA)[/TD]
[TD]
Estrogen
[/TD]
[TD]
Inhibits binding to the estrogen receptor.
[/TD][TD] [/TD]
[/TR]
[/TABLE]
Our Stolen Future: A list of endocrine-disrupting compounds