I didn't get from the text that no human would ever settle/reside either in or near Damascus ever again. Considering Isaiah 17 as a whole, reading the surrounding chapters, and considering the historical context in which it was written, it seems that it's talking about the events of Judah and Israel's "Assyrian Crisis."
. . . .
So maybe you are looking at the wrong Prophecy:
Jeremiah 50:41-42 (NKJV)
[SUP]
41 [/SUP] "
Behold, a people shall come from the north, And a great nation and many kings Shall be raised up from the ends of the earth.
[SUP]
42 [/SUP] They shall hold the bow and the lance; They
are cruel and shall not show mercy. Their voice shall roar like the sea; They shall ride on horses, Set in array, like a man for the battle, Against you, O daughter of Babylon.
Jeremiah 50:46 (NKJV)
[SUP]
46 [/SUP]
At the noise of the taking of Babylon The earth trembles, And the cry is heard among the nations.
Jeremiah 51:1 (NKJV)
[SUP]
1 [/SUP] Thus says the LORD: "Behold, I will raise up against Babylon, Against those who dwell in Leb Kamai,
A destroying wind.
Jeremiah 51:2-4 (NKJV)
[SUP]
2 [/SUP] And I will send winnowers to Babylon, Who shall winnow her and empty her land. For in the day of doom They shall be against her all around.
[SUP]
3 [/SUP] Against
her let the archer bend his bow, And lift himself up against
her in his armor. Do not spare her young men; Utterly destroy all her army.
[SUP]
4 [/SUP] Thus
the slain shall fall in the land of the Chaldeans,
{Kuwait - Desert Storm, but the prophecy has not been fully fulfilled YET.} And
those thrust through in her streets.
Jeremiah 51:6 (NKJV)
[SUP]
6 [/SUP]
Flee from the midst of Babylon, And every one save his life! Do not be cut off in her iniquity, For this
is the time of the LORD'S vengeance; He shall recompense her.
Jeremiah 51:11 (NKJV)
[SUP]
11 [/SUP]
Make the arrows bright! Gather the shields! The LORD has raised up the spirit of
the kings of the Medes {IRAN}.
For His plan is against Babylon to destroy it, Because it is the vengeance of the LORD, The vengeance for His temple.
Jeremiah 51:18 (NKJV)
[SUP]
18 [/SUP] They
are futile, a work of errors; In the time of their punishment
they shall perish.
Jeremiah 51:19-24 (NKJV)
[SUP]
19 [/SUP] . . . And
Israel is the tribe of His inheritance. The LORD of hosts
is His name.
[SUP]
20 [/SUP] "
You are My battle-ax and weapons of war: For
with you I will break the nation in pieces;With you I will destroy kingdoms;
[SUP]
21 [/SUP] With you I will break in pieces the horse and its rider; With you I will break in pieces the chariot and its rider;
[SUP]
22 [/SUP] With you also I will break in pieces man and woman; With you I will break in pieces old and young; With you I will break in pieces the young man and the maiden;
[SUP]
23 [/SUP] With you also I will break in pieces the shepherd and his flock; With you I will break in pieces the farmer and his yoke of oxen; And with you I will break in pieces governors and rulers.
[SUP]
24 [/SUP] "And I will repay Babylon And all the inhabitants of Chaldea For all the evil they have done In Zion in your sight," says the LORD.
Jeremiah 51:26 (NKJV)
[SUP]
26 [/SUP] They shall not take from you a stone for a corner Nor a stone for a foundation, But
you shall be desolate forever," says the LORD.
Jeremiah 51:27-29 (NKJV)
[SUP]
27 [/SUP] Set up a banner in the land, Blow the trumpet among the nations! Prepare the nations against her,
Call the kingdoms together against her: Ararat, Minni, and Ashkenaz. Appoint a general against her; Cause the horses to come up like the bristling locusts.
[SUP]
28 [/SUP]
Prepare against her the nations,
With the kings of the Medes{IRAN}, Its governors and all its rulers,
All the land of his dominion.
[SUP]
29 [/SUP] And
the land will tremble and sorrow; For
every purpose of the LORD shall be performed against Babylon,
To make the land of Babylon a desolation without inhabitant.
Jeremiah 51:33 (NKJV)
[SUP]
33 [/SUP] For thus says the LORD of hosts, the God of Israel: "
The daughter of Babylon is like a threshing floor When it is time to thresh her; Yet a little while And the time of her harvest will come."
Jeremiah 51:41 (NKJV)
[SUP]
41 [/SUP] "Oh, how Sheshach is taken! Oh, how the praise of the whole earth is seized!
How Babylon has become desolate among the nations!
Jeremiah 51:43 (NKJV)
[SUP]
43 [/SUP]
Her cities are a desolation, A dry land and a wilderness, A land where no one dwells, Through which no son of man passes.
Jeremiah 51:47 (NKJV)
[SUP]
47 [/SUP] Therefore behold, the days are coming That I will bring judgment on the carved images of Babylon;
Her whole land shall be ashamed, And all her slain shall fall in her midst.
Jeremiah 51:50 (NKJV)
[SUP]
50 [/SUP]
You who have escaped the sword, Get away! Do not stand still! Remember the LORD afar off, And let Jerusalem come to your mind.
Jeremiah 51:58 (NKJV)
[SUP]
58 [/SUP] Thus says the LORD of hosts: "
The broad walls of Babylon shall be utterly broken, And
her high gates shall be burned with fire; The people will labor in vain, And the nations,
because of the fire; And they shall be weary."
Jeremiah 51:61-62 (NKJV)
[SUP]
61 [/SUP] And Jeremiah said to Seraiah, "When you arrive in Babylon and see it, and read all these words,
[SUP]
62 [/SUP] then you shall say, 'O LORD,
You have spoken against this place to cut it off, so that
none shall remain in it, neither man nor beast, but it shall be desolate forever.'
It sounds like to me, that ISRAEL with a coalition of Nations from the North, will get into a Nukear War with IRAN and the majority of the damage will take place in the territory of the old Babylonian Empire, and Damascus was once part of that Empire.
Damascus was ruled by Babylonians between 572 (Nebuchadnezzar) and 538 B.C.