Fellowship can indeed be lost.
With people...
In doing so we err, because of our flawed perceptions, dysfunctional pasts (and in many cases present), and then assume that God would relate to/with others as we would.
He doesn't. In Isaiah when God is telling us that His thoughts are higher than our thoughts, and His ways higher than our ways (see Isaiah 55), that phrase, in context, is speaking of the New Covenant, and in Isaiah 54, God talks about how He will never be angry with us again (again, context is pointing to the New Covenant in Christ):
4“Do not be afraid; you will not be put to shame.
Do not fear disgrace; you will not be humiliated.
You will forget the shame of your youth
and remember no more the reproach of your widowhood.
5For your Maker is your husband—
the Lord Almighty is his name—
the Holy One of Israel is your Redeemer;
he is called the God of all the earth.
6The Lord will call you back
as if you were a wife deserted and distressed in spirit—
a wife who married young,
only to be rejected,” says your God.
7“For a brief moment I abandoned you,
but with deep compassion I will bring you back.
8In a surge of anger
I hid my face from you for a moment,
but with everlasting kindness
I will have compassion on you,”
says the Lord your Redeemer.
9“To me this is like the days of Noah,
when I swore that the waters of Noah would never again cover the earth.
So now I have sworn not to be angry with you,
never to rebuke you again.
10Though the mountains be shaken
and the hills be removed,
yet my unfailing love for you will not be shaken
nor my covenant of peace be removed,”
says the Lord, who has compassion on you.
-JGIG
Do not fear disgrace; you will not be humiliated.
You will forget the shame of your youth
and remember no more the reproach of your widowhood.
5For your Maker is your husband—
the Lord Almighty is his name—
the Holy One of Israel is your Redeemer;
he is called the God of all the earth.
6The Lord will call you back
as if you were a wife deserted and distressed in spirit—
a wife who married young,
only to be rejected,” says your God.
7“For a brief moment I abandoned you,
but with deep compassion I will bring you back.
8In a surge of anger
I hid my face from you for a moment,
but with everlasting kindness
I will have compassion on you,”
says the Lord your Redeemer.
9“To me this is like the days of Noah,
when I swore that the waters of Noah would never again cover the earth.
So now I have sworn not to be angry with you,
never to rebuke you again.
10Though the mountains be shaken
and the hills be removed,
yet my unfailing love for you will not be shaken
nor my covenant of peace be removed,”
says the Lord, who has compassion on you.
-JGIG
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