There is a key to a complete understanding in realizing that, although the English translations may refer to him as such in any case, Adam is not referred to as man (ish) until God created woman (isha), and gave her to the man (ha'adam). According to the Hebrew understanding, this, shall we say, shows a separation of the men from the boys, and so a better understanding of the separation of sons from their fathers and their mothers in becoming men (and cleaving to their wives) would also follow.
Progeny are 'issues', according to old English, begotten of men and born of women, but Eve was not Adam's issue, she was [built; constructed; fashioned] take out of man. Although there is (typically) no progeny without woman's seed, sin enters through man's seed. So then, from what man's seed had Jesus was Jesus issue, considering God Himself claim Him His only begotten Son?