"Planes, Trains & Automobiles" (1987) at the end when Candy reveals to Steve Martin that his wife is dead and he's homeless
"The Untouchables" (1987) when Sean Connery dies and also at the end when Kevin Costner gives Andy Garcia Connery's callbox key in a handshake
Two very good choices.
Homeward Bound: At the end when the family is reunited with their pets but Shadow doesn't show up. They think he's dead and then BAM... He's back and it's the greatest "happily ever after" ever.
Best, children's movie, ever. Next to The Brave Little Toaster and The Fox and the Hound.