That's highly plausible.
Pre-tribbers are expecting God to come first before the anti-Christ. That means when the anti-Christ shows up giving out his mark on peoples' foreheads, the pre-tribbers will be expecting this: Revelation 22:4
4And they shall see his face; and
his name shall be in their foreheads.
I speculate that pre-tribbers would be showing up in droves to take what they believe in the name of God on their forehead. For the rest of us who reject this mark on the forehead, from the perspective of the pre-tribbers, what does that make us? Real genuine Christians who reject the mark of the beast would be viewed as the enemy, utterly sinful, and unrepentant by lost and confused pre-tribbers.
2 Thessalonians 1:6-8
6Seeing
it is a righteous thing with God to
recompense tribulation to them that trouble you;
7And to you who are troubled rest with us, when the Lord Jesus shall be revealed from heaven with his mighty angels,
8In flaming fire
taking vengeance on them that know not God, and that obey not the gospel of our Lord Jesus Christ:
It's entirely possible, in order to fulfill the prophecy of 2 Thessalonians 16-8, pre-tribbers could take commands from the anti-Christ, who they believe to be Jesus come to establish His millennial kingdom, to take vengeance on those who rejected the mark of the beast on their forehead. Again, from their perspective, they could be viewing us as those who "know not God, and that obey not the gospel of our Lord Jesus Christ..."
Think it's far-fetched that the persecution Christians will endure in the great tribulation could be from pre-tribbers? It's not.