In all honesty...everyone...guys gals...please don't use pickup lines...they don't work...I'm not speaking out of experience I'm just saying it...
Truth, man. I personally think it's not that hard to speak to the opposite gender in a kind, respectful manner. Just TALK to them! I think there's many proper ways to go about it, without coming off as offensive.
If the other side doesn't seem interested, I see no reason to force the issue. Still, I'm willing to believe there may have been some or a few cases of people with persistence showing success, but....I ain't about dat kind of stuff. (this isn't from personal experience. I'm just saying, y'know. Not an expert. Don't mind me and my jibberjabberish.)