Rev 17:3 So he carried me away in the spirit into the wilderness: and I saw a woman sit upon a scarlet coloured beast, full of names of blasphemy, having seven heads and ten horns.
The woman is described with being found with the blood of the prophets:
Rev 18:24 And in her was found the blood of prophets, and of saints, and of all that were slain upon the earth.
Rome was not accounted with the blood of the prophets, 1st century Jerusalem was:
(Mat 23:37 KJV) O Jerusalem, Jerusalem, thou that killest the prophets, and stonest them which are sent unto thee, how often would I have gathered thy children together, even as a hen gathereth her chickens under her wings, and ye would not!
There is no mechanism to transfer the blood guilt from 1st century AD Jerusalem to Rome.
Rome, the 4th beast and iron legs, invaded Israel and killed thousands.
The rebellion of the Maccabees also was a bloody war.
They killed John the Baptist and the apostles,
The children of Bethlehem.
And Jesus.
They killed thousands before and after the destruction of Jerusalem.
So they did have the blood of the prophets and the blood of Jesus on their hands, (Pilate washed his hands in vain).
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The woman is more than just the false religion of Rome,
She (false religion, creation worship) is traced to the tower of Babel,
Where it reappeared after the flood of Noah.
She does have the blood of the prophets on her hands,
As she has operated inside Israel as Baal worship and others forms as false religion.
But in this case, she is seen riding the Roman beast.
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If the woman in Rev 17 was Jerusalem,
The beast would be seen riding on top of her,
Because Rome dominated Jerusalem.
But Jerusalem never dominated Rome.
So the woman in Rev 17 cannot be Jerusalem.