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yes, actually, i like to challenge atheists to apply it to the cosmos as a system. it's almost always something they have never even considered, and they usually don't think that a 'Jesus nut' has ever heard of such a thing - if they've even heard of it themselves. i'm also fond of pointing out the observer effect ((re: de Broglie et al)) as it relates to corporeal reality as an whole.
Well the Incompleteness theorem shows the limitations of known axioms (statements established to be true through logic and reasoning within a particular subject specifically arithmetic using a set of rules).
For the people that have no idea what I'm talking about in short it means that any non trivial system cannot actually be proven because contradictions and incompleteness exits. Things that are not contradictory in one system, may be contradictory in another. It is basically impossible if you do not have all the known facts.
Assuming that the cosmos are real as they tell you they are you'd be running up against the fact that in an infinite cosmos you'd eventually run into many contradictions and unknown variables that would make it impossible to exist the way they tell you it exits.
The observer effect just goes to show that there is no absolute truth in any measurement because the very same experiment set up to observe something can alter the object that is being observed.