I suggest Matthew 10:22 does not say we can do that. I read it as giving us assurance to never lose sight of the fact that as we hold on through trials and travails eternal life in Christ awaits.Jesus said God would not revoke salvation; not that believers could not repudiate their salvation. (MT 10:22)
Salvation isn't tenuous. Of all that the father Gives him, he shall lose none. No one shall ever snatch them from my hand. I shall never cast them out.
Those are absolutes.
I don't think it spiritually healthy for us to think we're kinda saved as long as we don't slip up. Or lose faith.
Jesus assures us,he will never lose faith in us.