"He answered, 'Love the Lord your God with all your heart and with all your soul and with all your strength and with all your mind.'" Luke 10:27a.
It's quoted often. What does it look like in practical application? Are there feelings attached with it? What does this look like for you? How is it done?
Practical application...?
.........
I think if there's a feeling attached to it, I'd say it's discomfort. When the thought of saying something or doing something (for the cause of God) makes you very uncomfortable (your flesh crying out)...and you still choose to do it anyway (putting your flesh unto submission), whatever the consequences? No compromise?
THAT'S what I'd call practical application of Luke 10:27. When you love God more than what that action will cost you in a situation? You are showing you love God with every fiber of your being, no matter the cost.
I'd say practical application is real sacrifice (loss), in whatever form it takes in a person's life. If you willingly commit to any personal loss, for God, you've shown great love.
Abel and the lamb
Abraham and (potentially) his son
Daniel and (potentially) his life
Isaiah and his life (as well as other prophets)
The rich man and his wealth (would've been)
Christ and his life
The Apostles and their lives
...and in certain situations...
You and your reputation
You and your friends
You and your family
You and your money
You and your job
You and your personal time or rest
...any sacrifice you commit to God that would be a real loss to you as far as the world (or your flesh) is concerned, is - to me - when true love for God is applied.