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I know that this is a sensitive subject, being that he is your friend, but I am being honest here.
I would say that by being his best man, the message you would be sending is that you support it and condone his practices. If your friend is one who does not recognize same-sex as a sin, then you know what the consequences will be according to God's word, right?
"In like manner, Sodom and Gomorrah and the cities around them, who indulged in sexual immorality and pursued strange flesh, are on display as an example of those who sustain the punishment of eternal fire."
"Do not be yoked together with unbelievers. For what do righteousness and wickedness have in common? Or what fellowship can light have with darkness?"
Well, if you recognise that it’s a sin (homosexuality), then why would you go along with it?... I know it must be hard since that’s your best friend and all but you gotta ask yourself if this is right in your view or God’s view.
Personally, I wouldn’t do such thing, even if it were my own family - I fear God too much more than anything in this temporary world.