The wrath to come written of by Paul in Thessalonians was the very same wrath that John the Baptist spoke of which was the great tribulation.
The wrath to come/great tribulation occurred during the Roman siege of Jerusalem in the war of 66-70 AD. This is the same wrath that John spoke about in his revelation.
(Luke 23:28 But Jesus turning unto them said, Daughters of Jerusalem, weep not for me, but weep for yourselves, and for your children.)
(Luke 23:29 For, behold, the days are coming, in the which they shall say, Blessed are the barren, and the wombs that never bare, and the paps which never gave suck.)
(Luke 23:30 Then shall they begin to say to the mountains, Fall on us; and to the hills, Cover us.)
John uses the "fall on us" motif in his revelation - this places the 6th seal in the life time of the women that heard Jesus speak:
(Rev 6:12 And I beheld when he had opened the sixth seal, and, lo, there was a great earthquake; and the sun became black as sackcloth of hair, and the moon became as blood)
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(Rev 6:15 And the kings of the earth, and the great men, and the rich men, and the chief captains, and the mighty men, and every bondman, and every free man, hid themselves in the dens and in the rocks of the mountains)
(Rev 6:16 And said to the mountains and rocks, Fall on us, and hide us from the face of him that sitteth on the throne, and from the wrath of the Lamb)
(Rev 6:17 For the great day of his wrath is come; and who shall be able to stand?)