Never? Well, to state the obvious, you aren't gonna get results unless you ask a lot of ladies to meet up with you. To specify, not reach out to them; I mean ask to meet.
When I was on the dating sites, I went out with a lot of ladies. I learned through trial and error how to do it. You can waste time exchanging messages, or you can point blank ask them to meet you a specific day/time/place. (All first meetings are plutonic.) Sat/Sun coffee, either of you can leave at any time. Casual.
Most people on the site are there to date. But there are some who are already dating someone, or are simply going to be busy that day. Never assume why, just move on.
Some just want a fantasy pen pal... that's why you just ask them to meet you. If they can't that date/time, you can ask a second time if you think their worth it, but if they decline and don't make an alternative suggestion, just move on. You can exchange a few messages if it matters to them, but if she lives near you, you need to keep asking out other ladies in the meantime.
It's either a simple short meetup for a coffee, sat/sun lunch, or (more so for second dates) it's about the activity you're doing together: you're both going together to event you think they'd be interested in (like a play, bowling, painting date, live jazz, walk in the park, etc, if their profile says they enjoy.)
You're a fun, funny, decent, nice-looking guy. There's lots of women who'd be interested in you. But it's a numbers game. You don't know which 5 of the 10 ladies you ask to meet you are going to be the 5 that say yes, or the 2-3 that want a second date, or that you want a second date with. So, you have to ask the 10. And repeat. It's just the logistical reality, there's no point in being cross about it.